| Date | Opponent | Location | Time/Recap |
| 08/22/08 | Charlotte @ North Carolina | Chapel Hill, N.C. | 7:00 p.m. Gametracker |
| Loyola @ Virginia | Charlottesville, Va. | 7:00 p.m. Livestats | |
| Miami @ Stetson | DeLand, Fla. | 7:00 p.m. | |
| UAB @ Clemson | Clemson, S.C. | 7:00 p.m. Gametracker | |
| Utah @ Wake Forest | Winston-Salem, N.C. | 7:00 p.m. Gametracker | |
| Wofford @ NC State | Raleigh, N.C. | 7:00 p.m. Livestats | |
| 08/23/08 | Boston College @ Boston University | Boston, Mass. | 7:00 p.m. Gametracker |
| George Mason @ Maryland | College Park, Md. | 7:00 p.m. Gametracker | |
| Virginia Tech @ Davidson | Davidson, N.C. | 7:30 p.m. | |
| 08/24/08 | UCF @ Florida State | Tallahassee, Fla. | 1:00 p.m. |
| Western Carolina @ NC State | Raleigh, N.C. | 1:00 p.m. Livestats | |
| Coastal Carolina @ Duke | Durham, N.C. | 5:00 p.m. Livestats | |
| 08/27/08 | Presbyterian @ Clemson | Clemson, S.C. | 7:00 p.m. Gametracker |
| 08/29/08 | Florida State @ Penn State | State College, Pa. | 5:00 p.m. Gametracker |
| Liberty @ Virginia | Charlottesville, Va. | 6:00 p.m. Livestats | |
| Boston College vs. Oregon State | Palo Alto, Calif. | 7:00 p.m. | |
| Bucknell @ Maryland | College Park, Md. | 7:00 p.m. Gametracker | |
| Campbell @ Duke | Durham, N.C. | 7:00 p.m. Livestats | |
| Elon @ NC State | Raleigh, N.C. | 7:00 p.m. Livestats | |
| Evansville @ Virginia Tech | Blacksburg, Va. | 7:00 p.m. Livestats | |
| Florida International @ Miami | Coral Gables, Fla. | 7:00 p.m. Gametracker | |
| North Carolina @ Texas A&M | College Station, Texas | 7:00 p.m. Gametracker | |
| Wake Forest @ Francis Marion | Florence, S.C. | 7:00 p.m. | |
| 08/31/08 | Florida State vs. Connecticut | State College, Pa. | 11:00 a.m. Gametracker |
| North Carolina vs. Tennessee | College Station, Texas | 12:30 p.m. | |
| Florida Atlantic @ Miami | Coral Gables, Fla. | 1:00 p.m. Gametracker | |
| UNC Wilmington @ Wake Forest | Winston-Salem, N.C. | 1:00 p.m. Gametracker | |
| UNC Asheville @ Clemson | Clemson, S.C. | 2:00 p.m. Gametracker | |
| Boston College @ Stanford | Stanford, Calif. | 4:00 p.m. Gametracker | |
| Elon @ Maryland | College Park, Md. | 6:00 p.m. Gametracker | |
| UNC Greensboro @ Duke | Durham, N.C. | 6:00 p.m. Livestats | |
| VCU @ Virginia | Charlottesville, Va. | 6:00 p.m. Livestats | |
| George Mason @ Virginia Tech | Blacksburg, Va. | 7:00 p.m. Livestats | |
| 09/05/08 | Wake Forest vs. George Washington | Blacksburg, Va. | 3:30 p.m. Livestats |
| American @ Maryland | College Park, Md. | 5:00 p.m. Gametracker | |
| Brown @ Boston College | Chestnut Hill, Mass. | 5:00 p.m. | |
| Duke vs. Kentucky | Chapel Hill, N.C. | 5:00 p.m. Livestats | |
| Texas A&M @ Virginia Tech | Blacksburg, Va. | 6:00 p.m. Livestats | |
| Florida International @ Florida State | Tallahassee, Fla. | 7:00 p.m. Gametracker | |
| Miami @ Arkansas-Little Rock | Little Rock, Ark. | 7:00 p.m. | |
| Notre Dame @ North Carolina | Chapel Hill, N.C. | 7:00 p.m. Gametracker | |
| Virginia @ Georgia | Athens, Ga. | 7:00 p.m. Livestats | |
| Clemson @ South Carolina | Columbia, S.C. | 7:30 p.m. Gametracker | |
| VCU @ NC State | Raleigh, N.C. | 7:30 p.m. Livestats | |
| 09/07/08 | Wake Forest vs. Texas A&M | Blacksburg, Va. | 11:00 a.m. Livestats |
| Duke vs. Notre Dame | Chapel Hill, N.C. | 1:00 p.m. Livestats | |
| Miami @ Memphis | Memphis, Tenn. | 1:00 p.m. Gametracker | |
| Stetson @ NC State | Raleigh, N.C. | 1:00 p.m. Livestats | |
| Temple @ Maryland | College Park, Md. | 1:00 p.m. Gametracker | |
| Toledo @ Boston College | Chestnut Hill, Mass. | 1:00 p.m. | |
| Virginia vs. Auburn | Athens, Ga. | 1:00 p.m. Livestats | |
| George Washington @ Virginia Tech | Blacksburg, Va. | 1:30 p.m. Livestats | |
| Clemson vs. Francis Marion | Columbia, S.C. | 2:00 p.m. | |
| Kentucky @ North Carolina | Chapel Hill, N.C. | 3:00 p.m. Gametracker | |
| Florida @ Florida State | Tallahassee, Fla. | 4:30 p.m. Gametracker | |
| 09/10/08 | Purdue @ Miami | Coral Gables, Fla. | 7:00 p.m. Gametracker |
| 09/12/08 | Maryland vs. Dartmouth | Charlottesville, Va. | 4:30 p.m. Livestats |
| Virginia Tech vs. Cal State-Fullerton | Winston-Salem, N.C. | 5:00 p.m. | |
| Campbell @ NC State | Raleigh, N.C. | 7:00 p.m. Livestats | |
| Eastern Michigan @ Miami | Coral Gables, Fla. | 7:00 p.m. Gametracker | |
| Stony Brook @ Boston College | Chestnut Hill, Mass. | 7:00 p.m. | |
| William & Mary @ Virginia | Charlottesville, Va. | 7:00 p.m. Livestats | |
| Charlotte @ Wake Forest | Winston Salem, N.C. | 7:30 p.m. Gametracker | |
| Duke vs. Dayton | Columbus, Ohio | 7:30 p.m. Gametracker | |
| Florida State @ Auburn | Auburn, Ala. | 8:00 p.m. Gametracker | |
| North Carolina @ Stanford | Stanford, Calif. | 10:00 p.m. Gametracker | |
| 09/14/08 | Virginia Tech vs. Charlotte | Winston Salem, N.C. | 11:00 a.m. |
| Florida State vs. South Carolina | Auburn, Ala. | 12:00 p.m. Gametracker | |
| Maryland vs. William & Mary | Charlottesville, Va. | 12:00 p.m. Livestats | |
| Central Connecticut State @ Boston College | Chestnut Hill, Mass. | 1:00 p.m. | |
| Duke @ Ohio State | Columbus, Ohio | 1:00 p.m. Livestats | |
| NC State @ UMBC | Baltimore, Md. | 1:00 p.m. Livestats | |
| Cal State Fullerton @ Wake Forest | Winston-Salem, N.C. | 1:30 p.m. Gametracker | |
| Dartmouth @ Virginia | Charlottesville, Va. | 2:00 p.m. Livestats | |
| Southern California @ Clemson | Clemson, S.C. | 2:00 p.m. Gametracker | |
| North Carolina vs. Santa Clara | Palo Alto, Calif. | 3:00 p.m. | |
| 09/16/08 | BYU @ Miami | Coral Gables, Fla. | 7:00 p.m. Gametracker |
| 09/19/08 | Harvard @ Boston College | Chestnut Hill, Mass. | 4:00 p.m. |
| North Carolina vs. Georgia | Durham, N.C. | 5:00 p.m. | |
| Clemson @ Furman | Greenville, S.C. | 7:00 p.m. Gametracker | |
| NC State @ William & Mary | Williamsburg, Va. | 7:00 p.m. Livestats | |
| UNC Greensboro @ Wake Forest | Winston-Salem, N.C. | 7:00 p.m. Gametracker | |
| Fordham @ Duke | Durham, N.C. | 7:30 p.m. Livestats | |
| Miami @ UCLA | Los Angeles, Calif. | 8:00 p.m. Gametracker | |
| 09/21/08 | North Carolina vs. Fordham | Durham, N.C. | 12:00 p.m. |
| Florida Gulf Coast @ Florida State | Tallahassee, Fla. | 1:00 p.m. | |
| Mount St. Mary's @ Maryland | College Park, Md. | 1:00 p.m. | |
| NC State @ Old Dominion | Norfolk, Va. | 1:00 p.m. Livestats | |
| Miami vs. San Diego | Los Angeles, Calif. | 2:00 p.m. | |
| Virginia @ West Virginia | Morgantown, W.Va. | 2:00 p.m. Livestats | |
| Georgia @ Duke | Durham, N.C. | 2:30 p.m. Livestats | |
| James Madison @ Virginia Tech | Blacksburg, Va. | 7:00 p.m. Livestats | |
| 09/24/08 | North Florida @ NC State | Raleigh, N.C. | 3:00 p.m. Livestats |
| 09/25/08 | Boston College @ Duke | Durham, N.C. | 7:00 p.m. Livestats |
| Maryland @ Wake Forest | Winston-Salem, N.C. | 7:00 p.m. | |
| North Carolina @ Clemson | Clemson, S.C. | 7:00 p.m. | |
| Virginia @ Florida State | Tallahassee, Fla. | 7:00 p.m. | |
| Virginia Tech @ Miami | Coral Gables, Fla. | 7:00 p.m. | |
| 09/28/08 | Boston College @ Wake Forest | Winston-Salem, N.C. | 1:00 p.m. |
| Maryland @ North Carolina | Chapel Hill, N.C. | 1:00 p.m. | |
| Virginia @ Miami | Coral Gables, Fla. | 1:00 p.m. | |
| Virginia Tech @ Florida State | Tallahassee, Fla. | 1:00 p.m. | |
| NC State @ Duke | Durham, N.C. | 2:00 p.m. Livestats | |
| 10/02/08 | Florida State @ Maryland | College Park, Md. | 7:00 p.m. |
| Miami @ Boston College | Chestnut Hill, Mass. | 7:00 p.m. | |
| NC State @ Virginia | Charlottesville, Va. | 7:00 p.m. Livestats | |
| Virginia Tech @ Clemson | Clemson, S.C. | 7:00 p.m. | |
| North Carolina @ Duke | Durham, N.C. | 8:00 p.m. Livestats | |
| 10/05/08 | Florida State @ Boston College | Chestnut Hill, Mass. | 1:00 p.m. |
| Miami @ Maryland | College Park, Md. | 1:00 p.m. | |
| NC State @ Virginia Tech | Blacksburg, Va. | 1:00 p.m. Livestats | |
| Virginia @ Clemson | Clemson, S.C. | 2:00 p.m. | |
| North Carolina @ Wake Forest | Winston-Salem, N.C. | 6:00 p.m. | |
| 10/09/08 | Boston College @ North Carolina | Chapel Hill, N.C. | 7:00 p.m. |
| NC State @ Clemson | Clemson, S.C. | 7:00 p.m. | |
| Virginia @ Virginia Tech | Blacksburg, Va. | 7:00 p.m. Livestats | |
| Wake Forest @ Duke | Durham, N.C. | 7:00 p.m. Livestats | |
| 10/12/08 | Florida State @ Miami | Coral Gables, Fla. | 12:00 p.m. |
| Boston College @ NC State | Raleigh, N.C. | 1:00 p.m. Livestats | |
| Clemson @ Wake Forest | Winston-Salem, N.C. | 1:00 p.m. | |
| Duke @ Maryland | College Park, Md. | 1:00 p.m. | |
| Virginia Tech @ North Carolina | Chapel Hill, N.C. | 1:00 p.m. | |
| 10/15/08 | Longwood @ Virginia Tech | Blacksburg, Va. | 7:00 p.m. Livestats |
| 10/16/08 | Miami @ Clemson | Clemson, S.C. | 7:00 p.m. |
| Virginia @ Maryland | College Park, Md. | 7:00 p.m. | |
| Wake Forest @ Florida State | Tallahassee, Fla. | 7:00 p.m. | |
| 10/17/08 | North Carolina @ NC State | Raleigh, N.C. | 7:00 p.m. Livestats |
| 10/19/08 | Duke @ Florida State | Tallahassee, Fla. | 1:00 p.m. |
| Boston College @ Virginia | Charlottesville, Va. | 2:00 p.m. Livestats | |
| Maryland @ Virginia Tech | Blacksburg, Va. | 5:00 p.m. Livestats | |
| 10/23/08 | Clemson @ Florida State | Tallahassee, Fla. | 7:00 p.m. |
| Duke @ Miami | Coral Gables, Fla. | 7:00 p.m. | |
| Maryland @ Boston College | Chestnut Hill, Mass. | 7:00 p.m. | |
| NC State @ Wake Forest | Winston-Salem, N.C. | 7:00 p.m. | |
| 10/24/08 | North Carolina @ Virginia | Charlottesville, Va. | 7:00 p.m. Livestats |
| 10/26/08 | Maryland @ NC State | Raleigh, N.C. | 1:00 p.m. Livestats |
| Virginia Tech @ Boston College | Chestnut Hill, Mass. | 1:00 p.m. | |
| Wake Forest @ Miami | Coral Gables, Fla. | 1:00 p.m. | |
| Clemson @ Duke | Durham, N.C. | 2:00 p.m. Livestats | |
| 10/30/08 | Clemson @ Maryland | College Park, Md. | 7:00 p.m. |
| Duke @ Virginia | Charlottesville, Va. | 7:00 p.m. Livestats | |
| Florida State @ North Carolina | Chapel Hill, N.C. | 7:00 p.m. | |
| Miami @ NC State | Raleigh, N.C. | 7:00 p.m. Livestats | |
| Wake Forest @ Virginia Tech | Blacksburg, Va. | 7:00 p.m. Livestats | |
| 11/02/08 | Clemson @ Boston College | Chestnut Hill, Mass. | 1:00 p.m. |
| Florida State @ NC State | Raleigh, N.C. | 1:00 p.m. Livestats | |
| Miami @ North Carolina | Chapel Hill, N.C. | 1:00 p.m. | |
| Duke @ Virginia Tech | Blacksburg, Va. | 2:00 p.m. Livestats | |
| Wake Forest @ Virginia | Charlottesville, Va. | 2:00 p.m. Livestats |
